ABSTRACT
<p><b>OBJECTIVE</b>To optimize the different components proportions of the Realgar floating tablets for gastric retention by uniform design and correlation analysis.</p><p><b>METHOD</b>With the different dosage of hydroxypropyl methyl cellulose (HPMC) as the tablets frame matrix, uniform design and correlation analysis were used to optimize the best component proportions of formula, and to measure the dissolution of the tablets in vitro.</p><p><b>RESULT</b>Dissolution of the tablets in vitro was conformed to the expectation of experiment. The drug-release mechanism was by diffusion and corrosion at the same time.</p><p><b>CONCLUSION</b>The Realgar floating tablets for gastric retention achieved the goal of design, which demand sustained release and safety.</p>